Search results for "nervous tissues"

Lipid and homeostatic alterations in nervous tissues associated with aging and metabolic dysregulations: implication of gut microbiota and autophagy

2020

The retina and the brain are two nervous tissues rich in lipids. Aging and metabolic syndrome (MetS) are associated with functional and physiological alterations of these tissues as well as modifications in the composition of the gut microbiota. The global objective of this thesis work is to understand the lipid and homeostatic alterations in aging and MetS contexts in the retina and the brain. In a first study, we evaluated the impact of the modifications in the composition of the gut microbiota associated with aging on the lipid/fatty acid contents of the liver and the brain (cortex). We showed that colonization of germ-free mice with the gut microbiota of old mice modulated the hepatic e…